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anaplasma phagocytophilum
''Anaplasma phagocytophilum'' (formerly ''Ehrlichia phagocytophilum'') is a gram-negative bacterium that is unusual in its tropism to neutrophils. It causes anaplasmosis in sheep and cattle, also known as tick-borne fever and pasture fever, and also causes the zoonotic disease human granulocytic anaplasmosis.〔(Tick-Borne Fever ) reviewed and published by WikiVet, accessed 12 October 2011.〕
''Anaplasma phagocytophilum'' is a Gram-negative, obligate bacterium of neutrophils. It causes human granulocytic anaplasmosis, which is a tick-borne rickettsial disease. Because this bacterium invades neutrophils, it has a unique adaptation and pathogenetic mechanism.
==Biology==
''Anaplasma phagocytophilum'' is a small, obligate, intracellular bacterium with a Gram-negative cell wall. It is 0.2–1.0 μm and lacks a lipopolysaccharide biosynthetic machinery. The bacterium first resides in an early endosome, where it acquires nutrients for binary fission and grows into small groups called morulae. This bacterium prefers to grow within myeloid or granulocytic cells.〔
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